Scientist / Senior Scientist, Analytical Development

Company Overview:

Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self-replicating RNA, SignalPath targeted delivery, and logic-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety.

Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease. Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX-003 is designed for tumor-targeted expression and avoidance of off-target expression. STX-003, which is expected to enter the clinic in mid-2026, has the potential to be a major step forward for the fields of genetic medicine and oncology. Strand is also advancing STX-005, an in vivo CAR-T program designed to enable controlled, durable expression and repeat dosing. Founded by MIT synthetic biology pioneers, Strand has raised over $250 million and is headquartered in Boston, MA.

Become the next standout single strand!

Job Summary:

Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company.

We are looking for a highly motivated and innovative candidate for the role of Scientist/Senior Scientist of Analytical Development. The expectation is that the individual will lead advanced analytical characterization efforts across the organization. Reporting to the Associate Director of Analytical Development, the right candidate will be a strategic thinker that brings a leadership presence and enthusiasm for science to the Strand community.

Primary Responsibilities:

Drive the strategy, design, and execution of analytical characterization activities to support the development and advancement of RNA-based therapeutics and delivery platforms.

Generate, interpret, and communicate scientific data that informs product understanding, process development, manufacturing readiness, and key development decisions.

Advance organizational analytical capabilities by identifying, evaluating, and implementing innovative technologies, methodologies, and best practices.

Collaborate across internal functions and external partners to deliver high-quality scientific outcomes, ensuring alignment with project objectives, timelines, and regulatory expectations.

Provide technical leadership by mentoring scientists, fostering scientific excellence, maintaining thorough documentation, and contributing to regulatory and technical submissions.

Monitor emerging scientific and industry trends to identify opportunities that strengthen technical expertise, accelerate innovation, and enhance the organization's analytical capabilities.

Qualifications:

Bachelor's, Master's, or Ph.D. in Chemistry, Biochemistry, Chemical Engineering, Molecular Biology, Pharmaceutical Sciences, or a related scientific discipline required.

6+ years of demonstrated working experience developing and applying analytical methods to support biologics, nucleic acid therapeutics, or other complex modalities, with expertise in chromatographic, spectrometric, and/or biophysical characterization techniques.

Strong foundation in analytical method development, qualification, troubleshooting, and data interpretation within a research or drug development environment required.

Hands-on laboratory experience with molecular biology, biochemical, and/or nucleic acid workflows, coupled with a solid understanding of experimental design and scientific problem solving.

Proven ability to manage multiple priorities while maintaining documentation, producing high-quality technical reports, and contributing to regulatory or development documentation as appropriate.

Knowledge of process development, analytical development, or CMC activities supporting RNA LNP therapeutics, biologics, or other advanced therapeutic platforms required.

Ability to excel in a fast-paced, collaborative biotechnology environment, demonstrating adaptability, sound judgment, and a proactive approach to overcoming technical challenges.

Excellent interpersonal, written, and verbal communication skills with a track record of collaborating across multidisciplinary teams while working both independently and as a technical leader.

Strand offers a fast-paced, entrepreneurial, team-focused small company environment. We als…