Associate Director, Accounting
Mazetherapeutics · South San Francisco, CA · Posted Jun 29, 2026
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The Position
The Finance team is looking for an Associate Director, Accounting .
As the Associate Director, Accounting, you sit at the center of our company’s financial integrity and operational execution. You’ll lead core accounting operations, including payroll and month-end close, while ensuring accurate and timely financial reporting. With a hands-on mindset, you can balance getting into the details while setting direction, keeping the close moving forward and maintaining financial accuracy through attention to detail.
You are a key business owner of internal controls, partnering closely with our auditors and cross-functional teams to design, operate , and continuously strengthen a control environment that can scale with our organization. You proactively identify risks, streamline process , and drive thoughtful improvements that enhance efficiency without sacrificing rigor. You develop and lead a high-performing accounting team, bringing clarity, accountability, and curiosity to everything you do, helping the company grow with confidence.
This position reports to the VP , Corporate Controller.
The Impact You’ll Have
Accounting Operations Close – oversee day-to-day accounting operations including payroll, general ledger operations, and month-end close activities. Review journal entries, account reconciliations, and supporting schedules.
Payroll Oversight – Partner with People Operations, Accounting team, and third-party payroll provider to ensure accurate , compliant, and timely payroll processing.
SOX 404 Internal Controls – Own and maintain internal controls compliance for assigned processes, including documentation, risk assessments, control design, testing, and remediation. Serve as liaison with internal and external auditors for assigned areas.
Team Leadership Collaboration – Manage, mentor, and develop members of the accounting team by providing clear guidance, coaching, and performance feedback. Act as a trusted business partner to cross-functional stakeholders, including FP A, People Operations, and IT.
Process Improvement Systems – Drive continuous improvement with a focus on scalability, efficiency, and control effectiveness. Support accounting system controls through timely review of user access and change management. Ensure accounting policies, procedures, and process documentation are accurate , current, and scalable for future growth.
Leadership Competencies
Communication and Influence
Communicates the reasoning behind decisions to appropriate stakeholders.
Promotes open communication with internal and external stakeholders.
Fosters healthy and respectful debate.
Teamwork and Collaboration
Creates opportunities for team members to connect with others outside of team.
Manages conflict effectively between teams.
Openly values thoughts, opinions, and contributions of employees.
Execution and Results
Exercises astute judgment to make decisions with only the necessary amount of data.
Supports team members in creating their own resolutions to challenges and problems.
Works with other to reinforce process compliance, what good looks like, and risk mitigation.
Develop Others and Self
Articulates what good looks like throughout Maze.
Pursues development activities for continuous improvement of self and team.
What We’re Looking For
Bachelor’s degree in Accounting, Finance, or related field, with 10+ years of progressive accounting experience; CPA preferred
Proven experience leading payroll operations and the month-end close process
People management experience, leading 2+ direct reports
Deep experience with SOX404 and internal controls in a public company environment
Solid knowledge of US GAAP and public company requirements
Experience supporting external audits and working directly with auditors
Ability to come on site 2-3x per week
Hands on experience with NetSuite and ADP required, Coupa preferred
Big 4 public accounting experience preferred
Biotech and/or pre-revenue R D company experience preferred
About Maze Therapeutics
Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.
Our People
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both…