General Supervisor
Billiontoone · Union City, CA · Posted Jun 29, 2026
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A Rare Opportunity to Shape the Future of Genomics
Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.
Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.
If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.
We are looking for a driven General Supervisor (with California Clinical Laboratory Scientist License) to support UNITY, the only non-invasive prenatal test (NIPT) that can detect inherited disorders such as sickle cell disease, spinal muscular atrophy, and cystic fibrosis in the baby directly from maternal blood. These disorders are extremely severe, but early detection and intervention can significantly improve outcomes. You will lead and oversee our growing superstar CLIA team responsible for pregnancy blood sample processing in a high complexity, high-growth CLIA setting. The General Supervisor is an onsite position and reports to the Director of Laboratory Operations.
Shift Hours: Mon-Fri PM
Weekday PM, 20% differential
Responsibilities:
Lead clinical laboratory daily supervision in alignment with company values and mission
Hold General Supervisor delegation and responsibilities including oversight and support of day-to-day operations (Pre-analytical and Analytical), scheduling, and troubleshooting
Manage CLIA direct reports including licensed and/or unlicensed staff (CLS, Clinical Laboratory Assistants)
Oversee continuous process improvement projects including reagent quality control, tech transfer, troubleshooting, training, and validations
Facilitate communication between laboratory teams and other departments or stakeholders
Participate in recruiting efforts and hiring to meet sample volume demands
Foster a collaborative team environment for continuous growth and building skillsets
Partial owner of and leading execution of company objectives and key results
Requirements:
Bachelor's degree in the chemical, physical or biological sciences
Current or previous supervisory experience that includes direct supervision of lab staff
Minimum of 4-5 years of CLS experience in a clinical setting (molecular and/or high-complexity laboratory experience preferred)
A current California Clinical Laboratory Scientist License that meets requirements for Testing Personnel under CLIA regulations (42 CFR, part 493) (ASCP, CGMBS or generalist license is required)
Hands-on training and experience with manual molecular biology protocols, including DNA extraction, PCR, and automated liquid handlers
Advanced knowledge of Google Docs, Word, Excel, basic statistics and familiarity with LIMS systems and Next-Generation Sequencing
Excellent leadership, communication, and interpersonal skills
Strong attention to detail and ability to work flexibly and well under given timeframes
Self-starter and dynamic team player with excellent verbal and written skills
Nice-To-Haves:
Previous CLIA General Supervisor experience
Start-up experience
Knowledge of medical genetics
Experience in a cell-free DNA setting
Benefits And Perks:
Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
Open, transparent culture that includes weekly Town Hall meetings
The ability to indirectly or directly change the lives of hundreds of thousands patients
Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
Extremely generous Family Bonding Leave for eligible employees (16 weeks, paid at 100%)
Supplemental fertility benefits coverage
Retirement savings program including a 4% Company match
Increase paid time off with increased tenure
Latest and greatest hardware (laptop, lab equipment, facilities)
Daily on-site lunches provided from top eateries
A variety of perks on campus (state of the art gym, restaurant)
Free on-site EV charging (compatible with all EVs, including Tesla)
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