Biologist

(ID: 2026-2563)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

Position Information:

Under this task order, the contractor will independently provide support services to satisfy the overall operational objectives of the NIH Clinical Center, Department of Transfusion Medicine, Human Leukocyte Antigen Laboratory. The primary objective is to provide services and deliverables through performance of support services.

Certifications Licenses

American Board of Histocompatibility and Immunogenetics certification eligible.

Field of Study

Genetics

Microbiology

Miscellaneous Biology

Software

MS Office Suite

Skills

Strong communications skills, both oral and written.

Excellent analytical, organizational and time management skills.

Deliverables:

Work products and documents related to performing work in the DTM HLA Laboratory, including specimen processing, DNA extraction and quantitation, molecular HLA typing utilizing polymerase chain reaction (PCR), SSP, SSO, SBT, NGS, agarose preparation and gel electrophoresis, interpretation of all HLA typing results and various HLA antibody screening methods and interpretation. - Ad-Hoc

Work products and documents related to the identification of unusual HLA antibody and typing patterns; maintain leadership and support role to staff; perform final review analysis process and determine any discrepancies which need resolution; participate in the review and audit of laboratory records and SOPs. - Ad-Hoc

Work products and documents related to maintaining documents related to the verification and recoding of specimens; maintain documents related to quality assurance practices; provide a leadership role in taking the initiative to implement changes upon request. - Ad-Hoc

Work products and documents related to test/assay development, validation and implementation of new equipment and reagents; perform validation and recording of specimens in all appropriate software-based applications. - Ad-Hoc

Work products and documents related to troubleshooting in the areas of the laboratory software applications and instrumentation; monitor the quality assurance practices in all aspects of laboratory work; coordinate the teaching process of laboratory staff regarding new procedures and techniques. - Ad-Hoc

Statement of Work Details:

Perform work in the DTM HLA Laboratory, including the following major laboratory procedures: - 1

Perform specimen processing - 2

DNA extraction and quantitation utilizing various manual and automated methods - 3

Molecular HLA typing utilizing polymerase chain reaction PCR, sequence specific primer SSP, sequence specific oligonucleotide SSO technology, and sequenced based typing SBT

Molecular HLA typing utilizing next generation sequencing

Next generation sequencing data analysis

Agarose preparation and gel electrophoresis; photo-documentation of results

Interpretation of all HLA typing results

Support the general HLA staff in communication with transplant groups and appropriate documentation

Perform troubleshooting on current HLA analysis software and database management systems and all facets of laboratory

Various HLA antibody screening and identification methods and interpretation

Work with staff on the identification of unusual HLA antibody and typing patterns; maintain leadership and support role to encourage staff members to understand the complexities of antibody identification and the other work they perform

Perform final review analysis process and determine any discrepancies which need resolution

Participate in the review and audit of laboratory records and standard operating procedures SOPs in order to improve the efficiency and effectiveness of the laboratory; maintain related documents

Participate in the review of QC and quality assurance records to assure that the laboratory is maintaining necessary levels of accreditation

Maintain documents related to keeping maintenance documentation and monitoring of quality assurance practices

Provide a leadership role in taking the initiative to implement changes upon request

Work with staff on test assay development, validation and implementation of new equipment and reagents in the sequencing area in order to provide a more efficient high-throughput test; maintain related documents

Collaborate with staff on the evaluation of any new reagents assays for antibody detection that may benefit the laboratory

Perform validation and recordi…