Accounting Manager, R&D (Non-Clinical)

About Summit:

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including:

Non-small Cell Lung Cancer (NSCLC)

HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.

HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

Colorectal Cancer (CRC)

HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.

Overview of Role:

The Accounting Manager, R D (Non-Clinical) plays a critical, hands-on role in owning and managing R D accruals and expense accounting for non-clinical trial activities across a global footprint (U.S., Europe, China). This role is central to ensuring R D expenses are accurately accrued, analyzed, and supported, with close collaboration across vendors, internal project managers, and cross functional teams.

This position requires a hands-on accounting leader who goes beyond transactional accounting to critically assess R D activity and ensure accruals accurately represent the business. Working cross functionally with R D, vendors, and project stakeholders across the U.S., Europe, and China, this role plays a key part in supporting global audits and statutory financial reporting in a dynamic, high growth environment.

Role and Responsibilities:

Own the end-to-end R D accrual and expense accounting process for nonclinical activities, ensuring costs are accurately captured and reflect underlying business activity

Prepare and review monthly journal entries and account reconciliations, exercising judgment to assess completeness, accuracy, and overall reasonableness

Partner closely with vendors, internal project managers, and cross functional R D teams to obtain data, validate assumptions, and support accrual calculations

Support R D cost areas including manufacturing, patient safety, biostatistics, CMC, supply chain, and non-trial clinical operations expenses

Play a key role in the monthly close process, contributing to continuous improvement, documentation, and close efficiency

Support global audits and statutory financial statements across the U.S., UK, and Switzerland by preparing schedules, analyses, and audit support

Contribute to internal controls, SOX readiness, and accounting process development as the company continues to scale

Ad-hoc tasks as assigned

All other duties as assigned

Experience, Education and Specialized Knowledge and Skills:

Bachelor’s degree in Accounting, Finance, Business, related field

A minimum of 5+ years of experience in accounting or finance with demonstrated ownership of accruals

Hands‑on experience with R D accruals in a biotech or pharmaceutical setting, including familiarity with complex R D cost structure

Demonstrated ability to apply judgment, evaluate assumptions, and assess the reasonableness of accruals in situations where inputs are incomplete or evolving

Experience working cross functionally to interpret activity, resolve issues, and ensure accurate financial outcomes

Exposure to global accounting environments, including supporting audits and statutory reporting across multiple jurisdictions

Working knowledge of internal controls and close processes, with experience helping build, refine, and improve accounting practices in a growing organization

Strong organizational skills, attention to detail, and the ability to operate effectively in a fastmoving, high growth setting

Experience with NetSuite, close manag…