Senior Director, Head of Transactions & Partnering
Revolutionmedicines · Redwood City, California, United States · Posted Jul 9, 2026
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Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
The Senior Director, Head of Transactions and Partnering is a senior leader within the Business Development organization responsible for leading the evaluation, structuring, negotiation, and execution of strategic business development transactions that support Revolution Medicines' corporate and portfolio objectives.
Reporting to the Vice President, Business Development, this individual serves as the company's transaction lead and principal negotiator across a broad range of strategic partnerships, including licensing, collaboration, co-development, alliance, option, platform, and other business development agreements. The role partners closely with Business Development leadership and cross-functional stakeholders across Research, Development, Commercial, Finance, Legal, Intellectual Property, and Executive Management to advance high-priority opportunities from initial assessment through successful execution.
The successful candidate will bring deep transaction expertise, strong business judgment, and exceptional negotiation skills, coupled with the ability to lead complex cross-functional teams and drive alignment among diverse stakeholders. This individual will play a critical role in enabling Revolution Medicines to establish and execute strategic partnerships that accelerate innovation, expand capabilities, and create long-term value for patients and shareholders.
Key Responsibilities:
Transaction Leadership and Execution
Lead the company's transaction activities, advancing prioritized opportunities from evaluation through execution.
Serve as the transaction lead for strategic business development opportunities, developing negotiation strategies and execution plans that maximize value and support corporate objectives.
Structure, negotiate, and execute a broad range of transactions, including licensing, collaboration, co-development, alliance, option, platform, and other strategic agreements.
Lead transaction processes from initial engagement through confidentiality agreements, term sheet development, definitive agreement negotiation, and transaction closing.
Develop creative transaction structures that appropriately balance strategic objectives, economics, operational considerations, and risk allocation.
Identify transaction risks and develop practical solutions that facilitate successful deal execution while protecting the company's interests.
Negotiation and Deal Structuring
Serve as Revolution Medicines' lead negotiator for strategic business development transactions.
Partner closely with finance and legal/transaction counsel to develop transaction structures, review and negotiate definitive agreements, and drive successful deal execution.
Collaborate with FP A, commercial, competitive intelligence, business development team members to evaluate transaction economics, valuation analyses, and investment considerations.
Lead negotiations involving scientific, clinical, commercial, intellectual property, operational, and financial elements of complex transactions.
Develop and execute negotiation strategies that maximize value creation while preserving long-term partnership success.
Cross-Functional Transaction Management
Lead cross-functional transaction teams, aligning scientific, clinical, commercial, financial, intellectual property, and legal stakeholders throughout the evaluation and negotiation process.
Partner closely with the Search Evaluation function within BD to coordinate diligence activities and ensure comprehensive assessment of strategic, scientific, operational, legal, and financial considerations.
Drive stakeholder alignment and facilitate efficient decision-making across multiple functions and organizational levels.
Establish clear transaction plans, governance processes, timelines, and accountability to support successful execution.
Collaborate with Alliance Management function in negotiations and structuring phase to enable a seamless handoff to operationalizing relationships after agreement execution.
Governance and Executive Decision Support
Drive opportunities from initial contact all the way through to executive decision-making, including triaging, evaluation, identification of internal champ…