Senior Manager, Analytical Operations
Sanabiotech · Cambridge, MA · Posted Jun 24, 2026
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About the role
Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who are passionate about delivering the possible to patients, and who lead with the desire to work on novel ideas. As a Senior Manager, Analytical Operations, you will report to the Senior Director, Analytical Development and Quality Control. You will lead the execution of routine analytical testing while overseeing the day-to-day operations of the Analytical Operations laboratory. In this role, you will partner closely with Analytical Development, Process Development/MSAT, Research, and Site Operations to support laboratory buildout and expansion, ensure timely delivery of high-quality data, and drive operational excellence. You will also play a key role in building and developing a high-performing team.
What you’ll do
Collaborate with Analytical Development and Site Operations to support laboratory buildout, maintenance, and expansion, including budgeting for reagents, consumables, and capital equipment
Oversee equipment installation, qualification, troubleshooting, and lifecycle management (calibration and maintenance)
Plan, schedule, and execute routine analytical testing to meet turnaround time requirements for Process Development/MSAT and Research teams
Ensure accurate and complete documentation of testing activities in electronic laboratory notebooks
Develop and monitor operational metrics to identify inefficiencies and drive continuous improvement in laboratory workflows
Implement semi-automated or automated solutions for assay performance monitoring and control trending
Lead and develop team members through regular feedback, coaching, and performance management
Influence cross-functional stakeholders and effectively prioritize multiple projects in a fast-paced environment
Promote a culture of scientific rigor, accountability, and continuous improvement
Contribute to hiring efforts and build a high-performing, collaborative team
What we’re looking for
Bachelor’s degree with 7+ years of relevant experience, or an equivalent combination of education and experience
Experience in cell therapy or a related field
Strong background in analytical testing, including flow cytometry and cell-based assays
Experience using tools for assay performance monitoring and data trending
Demonstrated experience managing direct reports and supporting career development
Highly collaborative team player, with experience interfacing between Analytical Development, Process Development, and/or Research
Working knowledge of regulatory requirements and quality standards (e.g. FDA, ICH, and USP/EP)
What will separate you from the crowd
Experience leading digital or laboratory automation initiatives
Experience working in a regulated, quality-driven environment
Hands-on experience supporting laboratory investigations and audits in a GMP setting
Experience with pluripotent stem cells and differentiation
What you should know
Occasional off-hours or weekend work may be required
There may be potential exposure to BSL2 biohazard materials
Physical Demands: You may be required to perform the following physical activities: standing, walking, and sitting for extended periods of time; frequent use of the hands, fingers, wrist, and greater arm to handle small materials, tools, boxes, and trays; lifting and carrying objects up to 10 Ibs; occasional overhead reaches and lifts; occasional lifts and reaches below the knee; occasional pushing and pulling of materials and objects with moderate forces; occasional crouching/kneeling, twisting, and squatting movements.
The base pay range for this position at commencement of employment is expected to be between $160,000 and $200,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience
How we work together for patients
Lead from every seat – we seek to understand, act with honesty, and engage in the crucial conversations
Thrive as a team – we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
Make it happen – we value vigorous debate, alignment around our decisions, and resilient execution
Get to know us
At Sana, we believe that a workforce with varied backgrounds strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.
Core to our values, we believe there is nothing more important than the health and wellness of you and your family. For benefit eligible employees, we cover a generous portion of the cost for employee health coverage, making high-quality care more accessible and affo…