CLIA Laboratory Supervisor, Oncology
Billiontoone · Menlo Park, CA · Posted Jul 6, 2026
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A Rare Opportunity to Shape the Future of Genomics
Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.
Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.
If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.
BillionToOne is seeking a Clinical Laboratory General Supervisor (GS) to support our Oncology product, Northstar, in a high-complexity CLIA laboratory environment. This role provides general supervision of personnel and daily laboratory operations, ensuring regulatory compliance, quality, and operational excellence across end-to-end cancer blood sample processing.
This is a hands-on leadership role in a fast-growing, high-throughput molecular diagnostics lab. The General Supervisor will serve as a key operational leader and first point of escalation for CLS and CLA, partnering closely with the Technical Supervisor, Laboratory Director, and Quality team.
This is an onsite position supporting the Monday–Friday PM Shift (1:30 PM – 10:00 PM).
Responsibilities:
General Supervision Leadership
Serve as a designated CLIA General Supervisor for high-complexity testing in accordance with 42 CFR Part 493 and CAP accreditation standards
Provide day-to-day supervision of laboratory personnel, including CLSs and CLAs, during the pre-analytic, analytic, and post-analytic phases of testing
Act as the primary escalation point for technical, operational, and personnel issues during assigned shifts
Oversee staffing, scheduling, shift handoffs, and workload distribution to ensure operational continuity
Laboratory Operations Testing
Perform and oversee high-complexity molecular oncology assays, supporting diagnostic testing for patient care
Ensure proper instrument operation, calibration, maintenance, and troubleshooting
Review, interpret, and verify test results and quality control data
Identify, investigate, and resolve deviations that may impact test performance or result integrity
Quality Compliance
Ensure compliance with CLIA, CAP, state, and local regulatory requirements
Perform, review, and document quality control, corrective actions, and preventive maintenance
Participate in inspection readiness, audits, and regulatory responses
Lead or support SOP development, review, and biennial updates
Training Continuous Improvement
Lead training, onboarding, and competency assessments for new and existing laboratory staff
Provide hands-on and theoretical training for new assays, processes, and instrumentation
Support process improvement initiatives, including assay validation, tech transfer, and troubleshooting
Partner cross-functionally with Quality, R D, and Operations to drive continuous improvement
Qualifications:
Active California Clinical Laboratory Scientist (CLS) license (or CGMBS/generalist license) meeting CLIA requirements for high-complexity testing
Bachelor’s degree in chemical, biological, physical, clinical laboratory science, or a related field
Minimum 4 years of clinical laboratory experience, including molecular and/or high-complexity testing
Meets CLIA General Supervisor qualifications under 42 CFR 493.1461, including appropriate education, training, and experience
Demonstrated hands-on experience with molecular biology techniques (e.g., DNA extraction, PCR, automated liquid handlers)
Strong working knowledge of LIMS, quality systems, and laboratory documentation
Proficiency with Google Docs, Excel, Word, and basic statistical analysis
Excellent attention to detail, organizational skills, and ability to perform under time-sensitive conditions
Strong written and verbal communication skills and a collaborative leadership style
Nice-To-Haves:
Prior experience serving as a CLIA General Supervisor
Startup or high-growth laboratory experience
Background in medical genetics or oncology diagnostics
Experience working with cell-free DNA (cfDNA) or next-generation sequencing workflows
Benefits And Perks:
Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
Open, transparent culture that includes weekly Town Hall me…