Senior Program Manager- Clinical Innovation

Twin Health

At Twin Health, we empower people to improve and prevent chronic metabolic diseases, like type 2 diabetes and obesity, with a new standard of care. Twin Health is the only company applying AI Digital Twin technology exclusively toward metabolic health.

We start by building a dynamic model of each person’s metabolism — drawing on thousands of data points from CGMs, smartwatches, and meal logs — that maps their personal path to better health. Guided by a dedicated clinical care team, our members have lowered their A1C below the diabetes range, achieved lasting weight loss, and reduced or even eliminated medications, all while living healthier, happier lives.

Working here

Our team at Twin Health is passionate, talented, and united by a shared purpose: to improve the metabolic health and happiness of our members. We believe in empowering every Twin to make a meaningful impact for our members, our clients, and each other, while enjoying a supportive, collaborative work environment.

Twin has been recognized not only for our innovation but also for our culture, including: Innovator of the Year by the Employer Health Innovation Roundtable (EHIR), selected to CB Insights’ Digital Health 150, and named one of Newsweek’s Top Most Loved Workplace® .

With more than $100 million raised in recent funding, including a $53 million Series E round in 2025 led by Maj Invest, and a $50 million investment in 2023 led by Temasek, Twin is scaling rapidly across the U.S. and globally. Backed by leading venture firms like ICONIQ Growth, Sequoia, Sofina, Temasek, and Peak XV, we are building the most impactful digital health company in the world.

Join us as we reinvent the standard of care in metabolic health.

Opportunity

We are seeking a clinically-informed, operationally-minded Senior Manager to own the end-to-end design and implementation of care models for Twin's most strategic clients. Reporting to the Senior Director of Clinical Performance and Innovation, this role is responsible for bringing new care models to life, from early discovery through pilot, launch, and steady-state performance management. These programs will be built with the member and client in mind, including health systems, integrated delivery networks, Medicare Advantage plans, and new product lines. You will be the connective tissue across the organization, corralling clinical operations, implementation, product, technology, finance, and senior leadership around a shared vision of success for each program.

Responsibilities

Own end-to-end program design and operational strategy for new care model implementations, from discovery and design through pilot, launch, and post-launch management. These programs span new client partnerships, new program types (e.g., hypertension), and adaptations of existing care models.

Design operationally sound care models for new clients by understanding their member population, existing care infrastructure, and strategic priorities. Translate that understanding into scalable workflow design, care team structures, member engagement strategies, and success metrics.

Manage operational implementation in real time: anticipate operational bottlenecks, diagnose issues as they emerge during pilot and launch, and drive solutions. This requires hands-on problem-solving, not step-back oversight.

Lead cross-functional collaboration across in partnership with clinical operations, implementation, product, technology, finance, and senior leadership to align on implementation approach, resolve tradeoffs, and keep initiatives moving forward.

Serve as a primary internal point of contact for strategic client partners, including health systems, integrated delivery networks, and Medicare Advantage plans, during implementation and steady-state operations. Build trusted relationships with client stakeholders, communicate progress and performance transparently, and surface and resolve issues before they escalate.

Develop and maintain operational frameworks, playbooks, and enablement materials that translate care model design into day-to-day practice for care teams, including routing logic, member prioritization, escalation pathways, and cross-functional handoffs.

In alignment with senior leadership, define success metrics for each implementation (e.g. clinical outcomes, operational efficiency, member satisfaction, financial performance) and build measurement infrastructure to track progress and accountability.

Manage up and across: communicate regularly with senior leadership on progress, risks, and strategic tradeoffs. Escalate issues with clarity and candor. Partner with peer leaders to solve problems that span functions.

For strategic client relationships, continue to own operational strategy and performance management into steady state, acting as the internal strategic operator for that partnership.

Contribute to the overall care model roadmap and product strategy by synthesizing implementation learnings, clinical ins…